Endocrine Abstracts

Lifelong thyroid health depends on establishment of thyroid gland structure and function during early life development. However, thyroid development can be disrupted and lead to early- or adult life thyroid disorders. Still, the molecular machinery underpinning thyroid gland development remains poorly understood, particularly after the onset of fetal thyroid function. Here we used bulk-RNA-barcoding and sequencing (BRB-seq) to map the thyroid gland transcriptome as it undergoe...

Long-lasting and/or delayed reproductive effects of developmental exposure to mixtures of environmental chemicals were investigated in rats. Wistar rats were exposed to mixtures of estrogenic or anti-androgenic endocrine disrupters in pregnancy and lactation, and effects in offspring at 12–18 months of age were studied. The mixture included 13 estrogenic and anti-androgenic chemicals, including phthalates, pesticides, u.v.-filters, bisphenol A, butylparaben and paracetamo...